Rev. DePano was born in Manila, Philippines in 1960. He is the fourth child of nine born to Nathanael, a lawyer and former Presiding Justice of the Philippines Court of Appeals, and Aurora, a school teacher and former head of a home economics department. He is a fourth-generation United Methodist minister.
After receiving his Master of Divinity from Claremont School of Theology, Rev. DePano served his internship at Rosewood UMC in Los Angeles.